User: Guest  Login
Document type:
journal article 
Author(s):
Wheeler, Michael A; Jaronen, Merja; Covacu, Ruxandra; Zandee, Stephanie E J; Scalisi, Giulia; Rothhammer, Veit; Tjon, Emily C; Chao, Chun-Cheih; Kenison, Jessica E; Blain, Manon; Rao, Vijayaraghava T S; Hewson, Patrick; Barroso, Andreia; Gutiérrez-Vázquez, Cristina; Prat, Alexandre; Antel, Jack P; Hauser, Russ; Quintana, Francisco J 
Title:
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. 
Abstract:
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational modeling, perturbation studies, and multiple sclerosis (MS) patient samples to evaluate the effects of environmental exposure on CNS inflammation. We found that the herbicide linuron amplifies ast...    »
 
Journal title abbreviation:
Cell 
Year:
2019 
Journal volume:
176 
Journal issue:
Pages contribution:
581-596.e18 
Language:
eng 
Print-ISSN:
0092-8674 
TUM Institution:
Klinik und Poliklinik für Neurologie