User: Guest  Login
Document type:
journal article 
Author(s):
Jensen, Poul Erik H; Warnke, Clemens; Ingenhoven, Kathleen; Piccoli, Luca; Gasis, Marcia; Hermanrud, Christina; Fernandez-Rodriguez, Blanca M; Ryner, Malin; Kramer, Daniel; Link, Jenny; Ramanujam, Ryan; Auer, Michael; Buck, Dorothea; Grummel, Verena; Bertotti, Elisa; Fissolo, Nicolas; Oliver-Martos, Begoña; Nytrova, Petra; Khalil, Michael; Guger, Michael; Rathmaier, Sandra; Sievers-Stober, Claudia; Lindberg, Raija L P; Hässler, Signe; Bachelet, Delphine; Aktas, Orhan; Donnellan, Naoimh; Lawton,...    »
 
Title:
Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study. 
Abstract:
Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-?) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-?-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-? ADA in patients' sera. For clinical samples, selection...    »
 
Journal title abbreviation:
J Neuroimmunol 
Year:
2019 
Journal volume:
326 
Pages contribution:
19-27 
Language:
eng 
Print-ISSN:
0165-5728 
TUM Institution:
Klinik und Poliklinik für Neurologie