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Document type:
journal article 
Author(s):
Schinner, Elisabeth; Wetzl, Veronika; Schramm, Andrea; Kees, Frieder; Sandner, Peter; Stasch, Johannes-Peter; Hofmann, Franz; Schlossmann, Jens 
Title:
Inhibition of the TGF? signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis. 
Abstract:
Agents that enhance production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) ameliorate the progression of renal fibrosis. However, the molecular mechanism of this process is not fully understood. We hypothesize that the antifibrotic effects of cGMP and cGMP-dependent kinase I (cGKI) are mediated via regulation of the TGF? signalling pathway, both via ERK and the Smad-dependent route. Kidney fibrosis was induced by unilateral ureter obstruction (UUO) in wild-type and cGKI-defici...    »
 
Journal title abbreviation:
FEBS Open Bio 
Year:
2017 
Journal volume:
Journal issue:
Pages contribution:
550-561 
Language:
eng 
TUM Institution:
Institut für Pharmakologie und Toxikologie