Login
- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Nazem, Amir; Tang, Chris C; Spetsieris, Phoebe; Dresel, Christian; Gordon, Marc L; Diehl-Schmid, Janine; Grimmer, Timo; Yakushev, Igor; Mattis, Paul J; Ma, Yilong; Dhawan, Vijay; Eidelberg, David
- Titel:
- A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia.
- Abstract:
- Introduction: The heterogeneity of behavioral variant frontotemporal dementia (bvFTD) calls for multivariate imaging biomarkers. Methods: We studied a total of 148 dementia patients from the Feinstein Institute (Center-A: 25 bvFTD and 10 Alzheimer's disease), Technical University of Munich (Center-B: 44 bvFTD and 29 FTD language variants), and Alzheimer's Disease Neuroimaging Initiative (40 Alzheimer's disease subjects). To identify the covariance pattern of bvFTD (behavioral variant frontotemporal dementia-related pattern [bFDRP]), we applied principal component analysis to combined 18F-fluorodeoxyglucose-positron emission tomography scans from bvFTD and healthy subjects. The phenotypic specificity and clinical correlates of bFDRP expression were assessed in independent testing sets. Results: The bFDRP was identified in Center-A data (24.1% of subject × voxel variance; P < .001), reproduced in Center-B data (P < .001), and independently validated using combined testing data (receiver operating characteristics-area under the curve = 0.97; P < .0001). The expression of bFDRP was specifically elevated in bvFTD patients (P < .001) and was significantly higher at more advanced disease stages (P = .035:duration; P < .01:severity). Discussion: The bFDRP can be used as a quantitative imaging marker to gauge the underlying disease process and aid in the differential diagnosis of bvFTD.
- Zeitschriftentitel:
- Alzheimers Dement (Amst)
- Jahr:
- 2018
- Band / Volume:
- 10
- Seitenangaben Beitrag:
- 583-594
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1016/j.dadm.2018.07.009
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/30417069
- TUM Einrichtung:
- Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
BibTeX