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- Document type:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; 1
- Author(s):
- Hayakawa, Yoku; Sakitani, Kosuke; Konishi, Mitsuru; Asfaha, Samuel; Niikura, Ryota; Tomita, Hiroyuki; Renz, Bernhard W; Tailor, Yagnesh; Macchini, Marina; Middelhoff, Moritz; Jiang, Zhengyu; Tanaka, Takayuki; Dubeykovskaya, Zinaida A; Kim, Woosook; Chen, Xiaowei; Urbanska, Aleksandra M; Nagar, Karan; Westphalen, Christoph B; Quante, Michael; Lin, Chyuan-Sheng; Gershon, Michael D; Hara, Akira; Zhao, Chun-Mei; Chen, Duan; Worthley, Daniel L; Koike, Kazuhiko; Wang, Timothy C
- Title:
- Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.
- Abstract:
- Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1 tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa. Cholinergic stimulation of the gastric epithelium induced nerve growth factor (NGF) expression, and in turn NGF overexpression within gastric epithelium expanded enteric nerves and promoted carcinogen... »
- Journal title abbreviation:
- Cancer Cell
- Year:
- 2017
- Journal volume:
- 31
- Journal issue:
- 1
- Pages contribution:
- 21-34
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.ccell.2016.11.005
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/27989802
- Print-ISSN:
- 1535-6108
- TUM Institution:
- II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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