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Dokumenttyp:
journal article 
Autor(en):
Hoadley, Katherine A; Yau, Christina; Hinoue, Toshinori; Wolf, Denise M; Lazar, Alexander J; Drill, Esther; Shen, Ronglai; Taylor, Alison M; Cherniack, Andrew D; Thorsson, Vésteinn; Akbani, Rehan; Bowlby, Reanne; Wong, Christopher K; Wiznerowicz, Maciej; Sanchez-Vega, Francisco; Robertson, A Gordon; Schneider, Barbara G; Lawrence, Michael S; Noushmehr, Houtan; Malta, Tathiane M; Cancer Genome Atlas Network; Stuart, Joshua M; Benz, Christopher C; Laird, Peter W; Caesar-Johnson, Samantha J; Demcho...    »
 
Titel:
Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer. 
Abstract:
We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin....    »
 
Zeitschriftentitel:
Cell 
Jahr:
2018 
Band / Volume:
173 
Heft / Issue:
Seitenangaben Beitrag:
291-304.e6 
Sprache:
eng 
Print-ISSN:
0092-8674 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie