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Document type:
journal article 
Author(s):
Aly, Lilian; Hemmer, Bernhard; Korn, Thomas 
Title:
From Leflunomide to Teriflunomide: Drug Development and Immunosuppressive Oral Drugs in the Treatment of Multiple Sclerosis. 
Abstract:
Immunosuppressive drugs have been used in the treatment of multiple sclerosis (MS) for a long time. Today, orally available second generation immunosuppressive agents have been approved or are filed for licensing as MS therapeutics. Due to semi-selective targeting of cellular processes, these second-generation immunosuppressive compounds might rather be immunomodulatory. For example, Teriflunomide inhibits the de novo pyrimidine synthesis and thus only targets rapidly proliferating cells, includ...    »
 
Journal title abbreviation:
Curr Neuropharmacol 
Year:
2017 
Journal volume:
15 
Journal issue:
Pages contribution:
874-891 
Language:
eng 
Print-ISSN:
1570-159X 
TUM Institution:
Klinik und Poliklinik für Neurologie; Lehrstuhl für Molekulare Neuroimmunologie (Prof. Korn)