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Document type:
journal article 
Author(s):
Blecha, Jan; Novais, Silvia Magalhaes; Rohlenova, Katerina; Novotna, Eliska; Lettlova, Sandra; Schmitt, Sabine; Zischka, Hans; Neuzil, Jiri; Rohlena, Jakub 
Title:
Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. 
Abstract:
Mitochondrial electron transport chain (ETC) targeting shows a great promise in cancer therapy. It is particularly effective in tumors with high ETC activity where ETC-derived reactive oxygen species (ROS) are efficiently induced. Why modern ETC-targeted compounds are tolerated on the organismal level remains unclear. As most somatic cells are in non-proliferative state, the features associated with the ETC in quiescence could account for some of the specificity observed. Here we report that qui...    »
 
Journal title abbreviation:
Free Radic Biol Med 
Year:
2017 
Journal volume:
112 
Pages contribution:
253-266 
Language:
eng 
Print-ISSN:
0891-5849 
TUM Institution:
Institut für Toxikologie und Umwelthygiene