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Titel:

Calcium {Imaging} of {Nerve}-{Mast} {Cell} {Signaling} in the {Human} {Intestine}.

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Buhner, Sabine; Barki, Natasja; Greiter, Wolfgang; Giesbertz, Pieter; Demir, Ihsan E.; Ceyhan, Guralp O.; Zeller, Florian; Daniel, Hannelore; Schemann, Michael
Abstract:
Introduction: It is suggested that an altered microenvironment in the gut wall alters communication along a mast cell nerve axis. We aimed to record for the first time signaling between mast cells and neurons in intact human submucous preparations. Methods: We used the Ca(2+) sensitive dye Fluo-4 AM to simultaneously image changes in intracellular calcium [Ca(+2)]i (%DeltaF/F) in neurons and mast cells. Data are presented as median with interquartile ranges (25/75%). Results: We recorded nerve r...     »
Stichworte:
Ca2+ imaging, CGRP, enteric nervous system, neuropeptides, human gut, neuro-immune, SP, VIP
Zeitschriftentitel:
Frontiers in physiology
Jahr:
2017
Band / Volume:
8
Seitenangaben Beitrag:
971
Sprache:
eng
Volltext / DOI:
doi:10.3389/fphys.2017.00971
Print-ISSN:
1664-042X 1664-042X
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