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Document type:
journal article 
Author(s):
Aucamp, J; Bronkhorst, AJ; Badenhorst, CPS; Pretorius, PJ 
Title:
The diverse origins of circulating cell-free DNA in the human body: a critical re-evaluation of the literature 
Abstract:
Since the detection of cell-free DNA (cfDNA) in human plasma in 1948, it has been investigated as a non-invasive screening tool for many diseases, especially solid tumours and foetal genetic abnormalities. However, to date our lack of knowledge regarding the origin and purpose of cfDNA in a physiological environment has limited its use to more obvious diagnostics, neglecting, for example, its potential utility in the identification of predisposition to disease, earlier detection of cancers, and...    »
 
Journal title abbreviation:
Biol Rev Camb Philos Soc 
Year:
2018 
Journal volume:
93 
Journal issue:
Pages contribution:
1649-1683 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1464-7931 
TUM Institution:
Institut für Laboratoriumsmedizin