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Document type:
journal article 
Author(s):
Ormanns, S; Haas, M; Remold, A; Kruger, S; Holdenrieder, S; Kirchner, T; Heinemann, V; Boeck, S 
Title:
The Impact of SMAD4 Loss on Outcome in Patients with Advanced Pancreatic Cancer Treated with Systemic Chemotherapy 
Abstract:
The role of the tumor suppressor mothers against decapentaplegic homolog 4 (SMAD4) has not yet been defined in patients (pts) with advanced pancreatic cancer (aPC). This translational research study was designed to evaluate the impact of tumoral SMAD4 loss on clinicopathological parameters and outcome in PC patients receiving palliative chemotherapy. Using immunohistochemistry, we examined SMAD4 expression in tumor tissue of 143 aPC pts treated within completed prospective clinical and biomarker...    »
 
Journal title abbreviation:
Int J Mol Sci 
Year:
2017 
Journal volume:
18 
Journal issue:
Pages contribution:
1094- 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Institut für Laboratoriumsmedizin