Mechanistic analysis of aliphatic (beta)-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action

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Document type:: Zeitschriftenaufsatz
Author(s):: Zhao, Weining; Lorenz, Nicola; Jung, Kirsten; Sieber, Stephan A.
Title:: Mechanistic analysis of aliphatic (beta)-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action
Abstract:: N-Acylhomoserine lactones are autoinducers of quorum sensing (QS) in Gram-negative bacteria. We exploit here the role of structurally related (beta)-lactones in the inhibition of Vibrio harveyi bioluminescence and identify a derivative with nanomolar potency. Surprisingly, QS was not affected and combined proteomic/biochemical studies revealed insights into the cellular mode of action.
Journal title:: Chemical communications (Cambridge, England)
Year:: 2016
Journal volume:: 52
Journal issue:: 80
Pages contribution:: 11971-11974
Fulltext / DOI:: doi:10.1039/c6cc05807h
Publisher:: Royal Society of Chemistry (RSC)
Print-ISSN:: 1359-7345
E-ISSN:: 1364-548X
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