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Document type:
journal article 
Author(s):
Ferizi, Mehrije; Aneja, Manish K; Balmayor, Elizabeth R; Badieyan, Zohreh Sadat; Mykhaylyk, Olga; Rudolph, Carsten; Plank, Christian 
Title:
Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts. 
Abstract:
Modified nucleotide chemistries that increase the half-life (T1/2) of transfected recombinant mRNA and the use of non-native 5'- and 3'-untranslated region (UTR) sequences that enhance protein translation are advancing the prospects of transcript therapy. To this end, a set of UTR sequences that are present in mRNAs with long cellular T1/2 were synthesized and cloned as five different recombinant sequence set combinations as upstream 5'-UTR and/or downstream 3'-UTR regions flanking a reporter ge...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2016 
Journal volume:
Pages contribution:
39149 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung; Klinik für Unfallchirurgie