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Document type:
journal article 
Author(s):
Finan, Brian; Ma, Tao; Ottaway, Nickki; Müller, Timo D; Habegger, Kirk M; Heppner, Kristy M; Kirchner, Henriette; Holland, Jenna; Hembree, Jazzminn; Raver, Christine; Lockie, Sarah H; Smiley, David L; Gelfanov, Vasily; Yang, Bin; Hofmann, Susanna; Bruemmer, Dennis; Drucker, Daniel J; Pfluger, Paul T; Perez-Tilve, Diego; Gidda, Jaswant; Vignati, Louis; Zhang, Lianshan; Hauptman, Jonathan B; Lau, Michele; Brecheisen, Mathieu; Uhles, Sabine; Riboulet, William; Hainaut, Emmanuelle; Sebokova, Elena;...    »
 
Title:
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. 
Abstract:
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This unimolecular dual incretin is derived from an intermixed sequence of GLP-1 and GIP, and demonstrated enhanced antihyperglycemic and insulinotropic efficacy relative to selective GLP-1 agonists. Notably, this superior efficacy translated across rod...    »
 
Journal title abbreviation:
Sci Transl Med 
Year:
2013 
Journal volume:
Journal issue:
209 
Pages contribution:
209ra151 
Language:
eng 
Print-ISSN:
1946-6234 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)