User: Guest  Login
Document type:
journal article 
Author(s):
Müller, Timo D; Lee, Sang Jun; Jastroch, Martin; Kabra, Dhiraj; Stemmer, Kerstin; Aichler, Michaela; Abplanalp, Bill; Ananthakrishnan, Gayathri; Bhardwaj, Nakul; Collins, Sheila; Divanovic, Senad; Endele, Max; Finan, Brian; Gao, Yuanqing; Habegger, Kirk M; Hembree, Jazzmin; Heppner, Kristy M; Hofmann, Susanna; Holland, Jenna; Küchler, Daniela; Kutschke, Maria; Krishna, Radha; Lehti, Maarit; Oelkrug, Rebecca; Ottaway, Nickki; Perez-Tilve, Diego; Raver, Christine; Walch, Axel K; Schriever, Sonja C...    »
 
Title:
p62 links ?-adrenergic input to mitochondrial function and thermogenesis. 
Abstract:
The scaffold protein p62 (sequestosome 1; SQSTM1) is an emerging key molecular link among the metabolic, immune, and proliferative processes of the cell. Here, we report that adipocyte-specific, but not CNS-, liver-, muscle-, or myeloid-specific p62-deficient mice are obese and exhibit a decreased metabolic rate caused by impaired nonshivering thermogenesis. Our results show that p62 regulates energy metabolism via control of mitochondrial function in brown adipose tissue (BAT). Accordingly, ad...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2013 
Journal volume:
123 
Journal issue:
Pages contribution:
469-78 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)