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Document type:
journal article 
Author(s):
Lockie, Sarah H; Stefanidis, Aneta; Tschöp, Matthias H; Oldfield, Brian J 
Title:
Combination cannabinoid and opioid receptor antagonists improves metabolic outcomes in obese mice. 
Abstract:
The CB1 receptor antagonist, rimonabant, causes weight loss but also produces undesirable psychiatric side effects. We investigated using a combination of rimonabant with the opioid receptor antagonists naloxone and norBNI to treat the metabolic sequelae of long-term high fat diet feeding in mice. This combination has previously been shown to have positive effects on both weight loss and mood related behaviour. Diet-induced obese mice were treated chronically with either low dose rimonabant (1 m...    »
 
Journal title abbreviation:
Mol Cell Endocrinol 
Year:
2015 
Journal volume:
417 
Pages contribution:
10-9 
Language:
eng 
Print-ISSN:
0303-7207 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)