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Document type:
journal article 
Author(s):
Um, Sung Hee; Sticker-Jantscheff, Melanie; Chau, Gia Cac; Vintersten, Kristina; Mueller, Matthias; Gangloff, Yann-Gael; Adams, Ralf H; Spetz, Jean-Francois; Elghazi, Lynda; Pfluger, Paul T; Pende, Mario; Bernal-Mizrachi, Ernesto; Tauler, Albert; Tschöp, Matthias H; Thomas, George; Kozma, Sara C 
Title:
S6K1 controls pancreatic ? cell size independently of intrauterine growth restriction. 
Abstract:
Type 2 diabetes mellitus (T2DM) is a worldwide heath problem that is characterized by insulin resistance and the eventual loss of ? cell function. As recent studies have shown that loss of ribosomal protein (RP) S6 kinase 1 (S6K1) increases systemic insulin sensitivity, S6K1 inhibitors are being pursued as potential agents for improving insulin resistance. Here we found that S6K1 deficiency in mice also leads to decreased ? cell growth, intrauterine growth restriction (IUGR), and impaired placen...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2015 
Journal volume:
125 
Journal issue:
Pages contribution:
2736-47 
Language:
eng 
Print-ISSN:
0021-9738 
TUM Institution:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)