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Document type:
journal article 
Author(s):
Keller, Simone; Kneissl, Julia; Grabher-Meier, Verena; Heindl, Stefan; Hasenauer, Jan; Maier, Dieter; Mattes, Julian; Winter, Peter; Luber, Birgit 
Title:
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis. 
Abstract:
Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR with the inhibitory antibody cetuximab may affect the motile and invasive behavior of tumor cells. Here, we evaluated the effects of EGFR signaling in gastric cancer cell lines to link the phenotypic behavior of the cells with their molecular characteristics.Phenotypic effects were analyzed i...    »
 
Journal title abbreviation:
BMC Cancer 
Year:
2017 
Journal volume:
17 
Journal issue:
Pages contribution:
845 
Language:
eng 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie