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Document type:
journal article 
Author(s):
Wartewig, Tim; Kurgyis, Zsuzsanna; Keppler, Selina; Pechloff, Konstanze; Hameister, Erik; Öllinger, Rupert; Maresch, Roman; Buch, Thorsten; Steiger, Katja; Winter, Christof; Rad, Roland; Ruland, Jürgen 
Title:
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis. 
Abstract:
T cell non-Hodgkin lymphomas are a heterogeneous group of highly aggressive malignancies with poor clinical outcomes. T cell lymphomas originate from peripheral T cells and are frequently characterized by genetic gain-of-function variants in T cell receptor (TCR) signalling molecules. Although these oncogenic alterations are thought to drive TCR pathways to induce chronic proliferation and cell survival programmes, it remains unclear whether T cells contain tumour suppressors that can counteract...    »
 
Journal title abbreviation:
Nature 
Year:
2017 
Journal volume:
552 
Journal issue:
7683 
Pages contribution:
121-125 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Lehrstuhl für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad); Institut für Allgemeine Pathologie und pathologische Anatomie