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Document type:
journal article 
Author(s):
Yang, TJ; Krausz, KW; Shou, M; Yang, SK; Buters, JT; Gonzalez, FJ; Gelboin, HV 
Title:
Inhibitory monoclonal antibody to human cytochrome P450 2B6. 
Abstract:
The human cytochrome P450 2B6 metabolizes, among numerous other substrates, diazepam, 7-ethoxycoumarin, testosterone, and phenanthrene. A recombinant baculovirus containing the human 2B6 cDNA was constructed and used to express 2B6 in Sf9 insect cells. The 2B6 was present at 1.8 +/- 0.4% of the total cellular protein and was purified to a specific content of 13.3 nmol/mg protein. Mice were immunized with the purified 2B6, and a total of 811 hybridomas were obtained from the fusion of NS-1 myelom...    »
 
Journal title abbreviation:
Biochem Pharmacol 
Year:
1998 
Journal volume:
55 
Journal issue:
10 
Pages contribution:
1633-40 
Language:
eng 
Print-ISSN:
0006-2952 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung