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Document type:
journal article 
Author(s):
Zaher, H; Buters, JT; Ward, JM; Bruno, MK; Lucas, AM; Stern, ST; Cohen, SD; Gonzalez, FJ 
Title:
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. 
Abstract:
Acetaminophen (APAP) hepatotoxicity is due to its biotransformation to a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI), that is capable of binding to cellular macromolecules. At least two forms of cytochrome P450, CYP2E1 and CYP1A2, have been implicated in this reaction in mice. To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional expression of CYP1A2 and CYP2E1 was produced by cross-breeding Cyp1a2-/- mice with Cyp2e...    »
 
Journal title abbreviation:
Toxicol Appl Pharmacol 
Year:
1998 
Journal volume:
152 
Journal issue:
Pages contribution:
193-9 
Language:
eng 
Print-ISSN:
0041-008X 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung