Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Buters, JT; Tang, BK; Pineau, T; Gelboin, HV; Kimura, S; Gonzalez, FJ 
Titel:
Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2. 
Abstract:
We investigated the involvement of CYP1A2 in the pharmacokinetics and metabolism of caffeine using mice lacking its expression (CYP1A2 -/-). The half-life of caffeine elimination from blood was seven times longer in the CYP1A2 -/- than wild-type mice. The clearance was concomitantly eight times slower. No parameter that could affect the pharmacokinetics differed between CYP1A2-/-and wild-type mice such as creatinine for kidney function; alanine aminotransferase, aspartate aminotransferase, alka...    »
 
Zeitschriftentitel:
Pharmacogenetics 
Jahr:
1996 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
291-6 
Sprache:
eng 
Print-ISSN:
0960-314X 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung