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Document type:
journal article 
Author(s):
Schoenen, H; Bodendorfer, B; Hitchens, K; Manzanero, S; Werninghaus, K; Nimmerjahn, F; Agger, EM; Stenger, S; Andersen, P; Ruland, J; Brown, GD; Wells, C; Lang, R 
Title:
Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. 
Abstract:
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-dibehenate (TDB) are potent adjuvants for Th1/Th17 vaccination that activate Syk-Card9 signaling in APCs. In this study, we have further investigated the molecular mechanism of innate immune activation by TDM and TDB. The Syk-coupling adapter protein FcRgamma was essential for macrophage activation and Th17 adjuvanticity. The FcRgamma-associated C-type lectin receptor Mincle was expressed in macro...    »
 
Journal title abbreviation:
J Immunol 
Year:
2010 
Journal volume:
184 
Journal issue:
Pages contribution:
2756-60 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Molekulare Immunologie