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Document type:
journal article 
Author(s):
Schäfer, K; Halle, M; Goeschen, C; Dellas, C; Pynn, M; Loskutoff, DJ; Konstantinides, S 
Title:
Leptin promotes vascular remodeling and neointimal growth in mice. 
Abstract:
OBJECTIVE: Human obesity is associated with elevated leptin levels and a high risk of death from cardiovascular disease. In the present study, we investigated the effects of leptin on vascular wound healing and arterial lesion growth in mice. METHODS AND RESULTS: Wild-type mice placed on an atherogenic, high-fat diet had elevated (9-fold) leptin levels compared with their counterparts maintained on normal chow, and the former demonstrated significantly enhanced neointimal thickening after caroti...    »
 
Journal title abbreviation:
Arterioscler Thromb Vasc Biol 
Year:
2004 
Journal volume:
24 
Journal issue:
Pages contribution:
112-7 
Language:
eng 
Print-ISSN:
1079-5642 
TUM Institution:
ventive und rehabilitative Sportmedizin