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Document type:
journal article 
Author(s):
Fiedler, B; Feil, R; Hofmann, F; Willenbockel, C; Drexler, H; Smolenski, A; Lohmann, SM; Wollert, KC 
Title:
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. 
Abstract:
Cardiac myocyte apoptosis during ischemia and reperfusion (I/R) is tightly controlled by a complex network of stress-responsive signaling pathways. One pro-apoptotic pathway involves the interaction of the scaffold protein TAB1 with p38 mitogen-activated protein kinase (p38 MAPK) leading to the autophosphorylation and activation of p38 MAPK. Conversely, NO and its second messenger cGMP protect cardiac myocytes from apoptosis during I/R. We provide evidence that the cGMP target cGMP-dependent pro...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2006 
Journal volume:
281 
Journal issue:
43 
Pages contribution:
32831-40 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie