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Document type:
journal article 
Author(s):
Meuth, SG; Kanyshkova, T; Meuth, P; Landgraf, P; Munsch, T; Ludwig, A; Hofmann, F; Pape, HC; Budde, T 
Title:
Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels 
Abstract:
By combining molecular biological, electrophysiological, immunological, and computer modeling techniques, we here demonstrate a counterbalancing contribution of TASK channels, underlying hyperpolarizing K+ leak currents, and HCN channels, underlying depolarizing I-h, to the resting membrane potential of thalamocortical relay (TC) neurons. RT-PCR experiments revealed the expression of TASK1, TASK3, and HCN1-4. Quantitative determination of mRNA expression levels and immunocytochemical staining de...    »
 
Journal title abbreviation:
J Neurophysiol 
Year:
2006 
Journal volume:
96 
Journal issue:
Pages contribution:
1517-1529 
Language:
eng 
Print-ISSN:
0022-3077 
TUM Institution:
Institut für Pharmakologie und Toxikologie