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Dokumenttyp:
journal article 
Autor(en):
Pellegata, NS; Quintanilla-Martinez, L; Siggelkow, H; Samson, E; Bink, K; Höfler, H; Fend, F; Graw, J; Atkinson, MJ 
Titel:
Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. 
Abstract:
MENX is a recessive multiple endocrine neoplasia-like syndrome in the rat. The tumor spectrum in MENX overlaps those of human multiple endocrine neoplasia (MEN) types 1 and 2. We mapped the MenX locus to the distal part of rat chromosome 4, excluding the homologs of the genes responsible for the MEN syndromes (RET and MEN1) and syndromes with an endocrine tumor component (VHL and NF1). We report the fine mapping of the disease locus and the identification of a homozygous frameshift mutation in C...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2006 
Band / Volume:
103 
Heft / Issue:
42 
Seitenangaben Beitrag:
15558-63 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie