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Dokumenttyp:
journal article 
Autor(en):
Kuhnast, B; Bodenstein, C; Wester, HJ; Weber, W 
Titel:
Carbon-11 labelling of an N-sulfonylamino acid derivative: a potential tracer for MMP-2 and MMP-9 imaging 
Abstract:
Matrix metalloproteinases (MMPs) are a family of proteinases that play an important role in cancer. Non invasive imaging of MMPs would allow the evaluation of MMP activity in cancer and the assessment of the response of MMP inhibitor based therapies. In this paper, we investigated the synthesis and labelling by methylation with [C-11]CH3I of an N-sulfonylamino acid derivative, the (2R)-3-methyl-2-[[4-[(4-methoxybenzoyl)amino]benzenesulfonyl]amino] butanoic acid, a selective and high potent MMP-2...    »
 
Zeitschriftentitel:
J Labelled Comp Radiopharm 
Jahr:
2003 
Band / Volume:
46 
Heft / Issue:
Seitenangaben Beitrag:
539-553 
Sprache:
eng 
Print-ISSN:
0362-4803 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik