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Document type:
journal article 
Author(s):
Bijvelds, MJ; Jorna, H; Verkade, HJ; Bot, AG; Hofmann, F; Agellon, LB; Sinaasappel, M; de Jonge, HR 
Title:
Activation of CFTR by ASBT-mediated bile salt absorption. 
Abstract:
In cholangiocytes, bile salt (BS) uptake via the apical sodium-dependent bile acid transporter (ASBT) may evoke ductular flow by enhancing cAMP-mediated signaling to the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. We considered that ASBT-mediated BS uptake in the distal ileum might also modulate intestinal fluid secretion. Taurocholate (TC) induced a biphasic rise in the short circuit current across ileal tissue, reflecting transepithelial electrogenic ion transport...    »
 
Journal title abbreviation:
Am J Physiol Gastrointest Liver Physiol 
Year:
2005 
Journal volume:
289 
Journal issue:
Pages contribution:
G870-9 
Language:
eng 
Print-ISSN:
0193-1857 
TUM Institution:
Institut für Pharmakologie und Toxikologie