User: Guest  Login
Document type:
journal article 
Author(s):
Schlossmann, J; Hofmann, F 
Title:
cGMP-dependent protein kinases in drug discovery. 
Abstract:
Cyclic guanosine-3', 5'-monophosphate (cGMP)-dependent protein kinases (cGKs) are key enzymes of nitric oxide-cGMP and natriuretic peptide signalling cascades. These kinases mediate most of the effects of cGMP-elevating drugs, such as nitrates and phosphodiesterase inhibitors. cGKs modulate smooth muscle relaxation (e.g. the vasculature, gastrointestinal tract, bladder and penile), platelet aggregation, renin release, intestinal secretion, learning and memory. Furthermore, several cGK substrates...    »
 
Journal title abbreviation:
Drug Discov Today 
Year:
2005 
Journal volume:
10 
Journal issue:
Pages contribution:
627-34 
Language:
eng 
Print-ISSN:
1359-6446 
TUM Institution:
Institut für Pharmakologie und Toxikologie