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Document type:
journal article 
Author(s):
Sausbier, M; Arntz, C; Bucurenciu, I; Zhao, H; Zhou, XB; Sausbier, U; Feil, S; Kamm, S; Essin, K; Sailer, CA; Abdullah, U; Krippeit-Drews, P; Feil, R; Hofmann, F; Knaus, HG; Kenyon, C; Shipston, MJ; Storm, JF; Neuhuber, W; Korth, M; Schubert, R; Gollasch, M; Ruth, P 
Title:
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. 
Abstract:
BACKGROUND: Abnormally elevated blood pressure is the most prevalent risk factor for cardiovascular disease. The large-conductance, voltage- and Ca2+-dependent K+ (BK) channel has been proposed as an important effector in the control of vascular tone by linking membrane depolarization and local increases in cytosolic Ca2+ to hyperpolarizing K+ outward currents. However, the BK channel may also affect blood pressure by regulating salt and fluid homeostasis, particularly by adjusting the renin-ang...    »
 
Journal title abbreviation:
Circulation 
Year:
2005 
Journal volume:
112 
Journal issue:
Pages contribution:
60-8 
Language:
eng 
Print-ISSN:
0009-7322 
TUM Institution:
Institut für Pharmakologie und Toxikologie