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Document type:
journal article 
Author(s):
Kribben, A; Feldkamp, T; Horbelt, M; Lange, B; Pietruck, F; Herget-Rosenthal, S; Heemann, U; Philipp, T 
Title:
ATP protects, by way of receptor-mediated mechanisms, against hypoxia-induced injury in renal proximal tubules. 
Abstract:
We examined the effect of ATP on hypoxia-induced injury in freshly isolated rat renal proximal tubules and compared it with the effects of stable ATP analogues and ATP degradation products. Extracellular ATP significantly reduced hypoxia-induced structural cell damage (lactate dehydrogenase release). P(2)-receptor agonistic ATP analogues, including 2'-methylthio-ATP (2-Me-S-ATP), were also protective. In contrast, the P(1)-agonistic degradation products AMP and adenosine were not protective. Hyp...    »
 
Journal title abbreviation:
J Lab Clin Med 
Year:
2003 
Journal volume:
141 
Journal issue:
Pages contribution:
67-73 
Language:
eng 
Print-ISSN:
0022-2143 
TUM Institution:
Abteilung für Nephrologie