Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells.

Dokumenttyp:: Letter; Letter
Autor(en):: Hipp, S; Ringshausen, I; Oelsner, M; Bogner, C; Peschel, C; Decker, T
Titel:: Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells.
Abstract:: Mammalian target of rapamycin (mTOR) inhibitors represent a new class of potential anticancer agents. The mTOR inhibitor, rapamycin, inhibited proliferation in three mantle cell lymphoma (MCL) cell lines and reduced cyclin D3 expression while cyclin D1 levels remained unchanged. This finding was confirmed in cells from a MCL patient.
Zeitschriftentitel:: Haematologica
Jahr:: 2005
Band / Volume:: 90
Heft / Issue:: 10
Seitenangaben Beitrag:: 1433-4
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/16219581
Print-ISSN:: 0390-6078
TUM Einrichtung:: III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
BibTeX

Vorkommen: