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Document type:
journal article 
Author(s):
Koopman, G; Mortier, D; Hofman, S; Niphuis, H; Fagrouch, Z; Norley, S; Sutter, G; Liljeström, P; Heeney, JL 
Title:
Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens. 
Abstract:
Candidate human immunodeficiency virus (HIV) vaccine strategies that induce strong cellular immune responses protect rhesus macaques that are infected with recombinant simian/human immunodeficiency virus SHIV89.6p from acute CD4+ T-cell loss and delay progression to AIDS. However, similar strategies have not proven as efficacious in the simian immunodeficiency virus (SIV)mac model of AIDS, an infection that causes a slow, steady loss of CD4+ T-cell function and numbers in rhesus macaques similar...    »
 
Journal title abbreviation:
J Gen Virol 
Year:
2004 
Journal volume:
85 
Journal issue:
Pt 10 
Pages contribution:
2915-24 
Language:
eng 
Print-ISSN:
0022-1317 
TUM Institution:
Institut für Virologie