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Document type:
journal article 
Author(s):
Herrmann, F; Lehr, HA; Drexler, I; Sutter, G; Hengstler, J; Wollscheid, U; Seliger, B 
Title:
HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway. 
Abstract:
Because of its amplification and/or overexpression in many human tumors, the HER-2/neu proto-oncogene represents an attractive target for T-cell-mediated vaccination strategies. However, overexpression of oncogenes is often associated with defective expression of components of the MHC class I antigen-processing machinery (APM), thereby resulting in an immune escape phenotype of oncogene-transformed cells. To determine whether HER-2/neu influences the MHC class I antigen-processing pathway, the e...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2004 
Journal volume:
64 
Journal issue:
Pages contribution:
215-20 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Institut für Virologie