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Document type:
journal article 
Author(s):
Mäkitalo, B; Lundholm, P; Hinkula, J; Nilsson, C; Karlén, K; Mörner, A; Sutter, G; Erfle, V; Heeney, JL; Wahren, B; Biberfeld, G; Thorstensson, R 
Title:
Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen. 
Abstract:
The immunogenicity and protective efficacy of a DNA and recombinant modified vaccinia Ankara (MVA) vaccine administered by two different routes were investigated. DNA expressing HIV-1 IIIB env, gag, RT, rev, tat and nef, and MVA expressing HIV-1 IIIB nef, tat and rev and simian immunodeficiency virus (SIV) macJ5 gag/pol and vaccinia HIV-1 env, were used as immunogens. Four cynomolgus macaques received DNA intramuscularly (i.m.) at month 0 and intrarectally (i.r.) and intra-orally (i.o.) at 2 mon...    »
 
Journal title abbreviation:
J Gen Virol 
Year:
2004 
Journal volume:
85 
Journal issue:
Pt 8 
Pages contribution:
2407-19 
Language:
eng 
Print-ISSN:
0022-1317 
TUM Institution:
Institut für Virologie