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- Document type:
- Journal Article; Clinical Trial; Randomized Controlled Trial
- Author(s):
- Zimmermann, T; Gulyas, A; Bauer, CP; Steinkamp, G; Trautmann, M
- Title:
- Salmeterol versus sodium cromoglycate for the protection of exercise induced asthma in children--a randomised cross-over study.
- Abstract:
- OBJECTIVE: Physical activity is an important and frequent trigger of airways obstruction in asthmatic children. We aimed to compare the efficacies of 50 microg salmeterol twice daily and 2 mg SCG four times daily with respect to protection from exercise induced bronchoconstriction (EIB). METHODS: Twenty seven children and adolescents aged 4 to 16 years with mild or moderate exercise induced asthma (FEV1 70% to 90% predicted) were admitted to the study. Exercise challenge was performed on a treadmill using a predefined protocol in order to produce 10 minutes of exercise at near-maximum targets. The trial had a randomised, cross-over design comprising a 3-day run-in period and two 7-day treatment periods, separated by a one-week washout period. RESULTS: The mean protective efficacy of salmeterol was larger than that of SCG. A difference between treatments of 39.7% (95% CI, - 0,8 to 68.9%) in favour of salmeterol was calculated using a Hodges-Lehmann-estimate. The maximum post-challenge fall in FEV subset 1 was significantly lower (p<0.001) after salmeterol than after SCG (- 5.6 +/- 6.4% vs. -12.1 +/- 9.3%, respectively). In addition, salmeterol improved base-line lung function to a greater degree than SCG. FEV1 increased by 0.4 l/sec after salmeterol, whereas no improvement was observed after SCG. CONCLUSIONS: A one-week treatment with salmeterol 50 microg b.i.d in asthmatic children and adolescents provided better protection against EIB and improved baseline lung function as compared to SCG four times daily.
- Journal title abbreviation:
- Eur J Med Res
- Year:
- 2003
- Journal volume:
- 8
- Journal issue:
- 9
- Pages contribution:
- 428-34
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/14555299
- Print-ISSN:
- 0949-2321
- TUM Institution:
- Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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