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Document type:
journal article 
Author(s):
Fahrig, R; Quietzsch, D; Heinrich, JC; Heinemann, V; Boeck, S; Schmid, RM; Praha, C; Liebert, A; Sonntag, D; Krupitza, G; Hänel, M 
Title:
RP101 improves the efficacy of chemotherapy in pancreas carcinoma cell lines and pancreatic cancer patients. 
Abstract:
RP101 [(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU)], which supports apoptosis and prevents the acquisition of chemoresistance, was tested in cultured human pancreatic tumor cells. RP101 downregulated uridine phosphorylase, a marker of poor prognosis, and APEX1, which is involved in DNA repair, and repressed Stat3 and its target vascular endothelial growth factor. Furthermore, RP101 activated antitumor immunity as demonstrated by enhanced cytolytic activity of NK-92 natural killer cells. This was...    »
 
Journal title abbreviation:
Anticancer Drugs 
Year:
2006 
Journal volume:
17 
Journal issue:
Pages contribution:
1045-56 
Language:
eng 
Print-ISSN:
0959-4973 
TUM Institution:
II. Medizinische Klinik und Poliklinik