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- Dokumenttyp:
- Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Autor(en):
- Yfanti, C; Nielsen, AR; Akerström, T; Nielsen, S; Rose, AJ; Richter, EA; Lykkesfeldt, J; Fischer, CP; Pedersen, BK
- Titel:
- Effect of antioxidant supplementation on insulin sensitivity in response to endurance exercise training.
- Abstract:
- While production of reactive oxygen and nitrogen species (RONS) is associated with some of the beneficial adaptations to regular physical exercise, it is not established whether RONS play a role in the improved insulin-stimulated glucose uptake in skeletal muscle obtained by endurance training. To assess the effect of antioxidant supplementation during endurance training on insulin-stimulated glucose uptake, 21 young healthy (age 29 ± 1 y, BMI 25 ± 3 kg/m(2)) men were randomly assigned to either an antioxidant [AO; 500 mg vitamin C and 400 IU vitamin E (?-tocopherol) daily] or a placebo (PL) group that both underwent a supervised intense endurance-training program 5 times/wk for 12 wk. A 3-h euglycemic-hyperinsulinemic clamp, a maximal oxygen consumption (Vo(2max)) and maximal power output (P(max)) test, and body composition measurements (fat mass, fat-free mass) were performed before and after the training. Muscle biopsies were obtained for determination of the concentration and activity of proteins regulating glucose metabolism. Although plasma levels of vitamin C (P < 0.05) and ?-tocopherol (P < 0.05) increased markedly in the AO group, insulin-stimulated glucose uptake increased similarly in both the AO (17.2%, P < 0.05) and the PL (18.9%, P < 0.05) group in response to training. Vo(2max) and P(max) also increased similarly in both groups (time effect, P < 0.0001 for both) as well as protein content of GLUT4, hexokinase II, and total Akt (time effect, P <= 0.05 for all). Our results indicate that administration of antioxidants during strenuous endurance training has no effect on the training-induced increase in insulin sensitivity in healthy individuals.
- Zeitschriftentitel:
- Am J Physiol Endocrinol Metab
- Jahr:
- 2011
- Band / Volume:
- 300
- Heft / Issue:
- 5
- Seitenangaben Beitrag:
- E761-70
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1152/ajpendo.00207.2010
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/21325105
- Print-ISSN:
- 0193-1849
- TUM Einrichtung:
- Frauenklinik und Poliklinik
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