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Document type:
journal article 
Author(s):
Heit, A; Maurer, T; Hochrein, H; Bauer, S; Huster, KM; Busch, DH; Wagner, H 
Title:
Cutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cells. 
Abstract:
Covalent linkage of immunostimulatory CpG DNA to OVA results in CpG DNA-aided cross-presentation of OVA by dendritic cells (DCs). In vivo, cross-presentation is conditional for cross-priming of OVA-specific CD8 T cells. In this study, we investigated the involvement of the CpG DNA receptor Toll-like receptor (TLR)9 in CpG DNA-aided cross-presentation and cross-priming. Although CpG DNA-aided cross-presentation is not altered in TLR9-deficient cells, TLR9 is required for maturation of APC allowin...    »
 
Journal title abbreviation:
J Immunol 
Year:
2003 
Journal volume:
170 
Journal issue:
Pages contribution:
2802-5 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene ; Urologische Klinik und Poliklinik