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- Dokumenttyp:
- Clinical Trial; Journal Article; Randomized Controlled Trial; Article
- Autor(en):
- Skurk, T; Lee, YM; Nicuta-Rölfs, TO; Haastert, B; Wirth, A; Hauner, H
- Titel:
- Effect of the angiotensin II receptor blocker candesartan on fibrinolysis in patients with mild hypertension.
- Abstract:
- AIM: Impaired fibrinolysis is frequently observed in patients with the metabolic syndrome. Aim of the study was to examine the short-term effect of angiotensin II receptor blockade on the fibrinolytic system. METHODS: Seventy-four patients with mild hypertension were randomly assigned to a 7-day treatment period with either 16 mg candesartan cilexetil or placebo. Several variables of the fibrinolytic system such as plasminogen activator inhibitor-1 (PAI-1) antigen and activity, tissue plasminogen activator (t-PA) antigen and activity as well as circulating t-PA/PAI-1 complexes were determined. RESULTS: At baseline, the body mass index but not blood pressure was positively associated with PAI-1 antigen (r=0.314, p<0.01) and PAI-1 activity (r=0.425, p<0.01) but negatively with t-PA activity (r=-0.187, p < 0.05). A 7-day treatment with 16 mg candesartan cilexetil resulted in a significant greater reduction of diastolic blood pressure (-10.3 +/- 10.8 mmHg vs.-5.8 +/- 8.5 mmHg, p=0.03). However, there was no significant effect of candesartan on all parameters of the fibrinolytic system under investigation, i.e. circulating PAI-1 antigen, PAI-1 activity, t-PA antigen, t-PA activity and t-PA/PAI-1 complexes. Furthermore, candesartan did not affect the characteristic circadian pattern of the variables of the fibrinolytic system. CONCLUSION: We conclude that short-term blockade of the angiotensin II receptor subtype 1 with candesartan does not have an impact on fibrinolysis in patients with mild hypertension.
- Zeitschriftentitel:
- Diabetes Obes Metab
- Jahr:
- 2004
- Band / Volume:
- 6
- Heft / Issue:
- 1
- Seitenangaben Beitrag:
- 56-62
- Sprache:
- eng
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/14686964
- Print-ISSN:
- 1462-8902
- TUM Einrichtung:
- Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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