User: Guest  Login
Document type:
journal article 
Author(s):
Eifan, AO; Furukido, K; Dumitru, A; Jacobson, MR; Schmidt-Weber, C; Banfield, G; Durham, SR; Nouri-Aria, KT 
Title:
Reduced T-bet in addition to enhanced STAT6 and GATA3 expressing T cells contribute to human allergen-induced late responses. 
Abstract:
T-bet and GATA-3 are transcriptional factors involved in Th1 and Th2 cell differentiation, although their concomitant roles at protein levels in target organs during human allergic disease have not been assessed.We investigated the expression of T-bet and GATA-3 in nasal and cutaneous models of Th2 (grass-pollen allergen) and a cutaneous model of Th1 (PPD) responses in man.Nasal biopsies were obtained at 8 h and skin biopsies at 8 and 48 h after allergen and PPD challenges, respectively, from 10...    »
 
Journal title abbreviation:
Clin Exp Allergy 
Year:
2012 
Journal volume:
42 
Journal issue:
Pages contribution:
891-900 
Language:
eng 
Print-ISSN:
0954-7894 
TUM Institution:
r Molekulare Allergologie und Umweltforschung