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Document type:
journal article 
Author(s):
Beyerle, A; Braun, A; Banerjee, A; Ercal, N; Eickelberg, O; Kissel, TH; Stoeger, T 
Title:
Inflammatory responses to pulmonary application of PEI-based siRNA nanocarriers in mice. 
Abstract:
Polymeric non-viral vector systems for pulmonary application of siRNA are promising carriers, but have failed to enter clinical trials because of safety and efficiency problems. Therefore, improving their transfection efficiency, as well as their toxicological profile, is the subject of intensive research efforts. Six different poly(ethylene imine) (PEI)-based nanocarriers, with hydrophilic and hydrophobic PEG modifications, were toxicologically evaluated for pulmonary application in mice. Nanoc...    »
 
Journal title abbreviation:
Biomaterials 
Year:
2011 
Journal volume:
32 
Journal issue:
33 
Pages contribution:
8694-701 
Language:
eng 
Print-ISSN:
0142-9612 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung