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- Document type:
- Journal Article; Article
- Author(s):
- Brockow, K; Akin, C; Huber, M; METCALFE, DD
- Title:
- IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis.
- Abstract:
- Mastocytosis is often associated with organ involvement and hematological disorders. Patients may also exhibit elevated levels of plasma IL-6. To gain insight into the relevance of this observation, we correlated plasma levels of IL-6 and soluble IL-6 receptor (sIL-6R) with multiple disease parameters in 29 patients with mastocytosis. Mean plasma IL-6 levels were elevated in patients compared to healthy controls (P < 0.0001). Disease category significantly correlated with plasma IL-6 levels, as did severity of bone marrow pathology, organomegaly, and extent of skin involvement. In plasma, there was a positive correlation of IL-6 to total tryptase, alkaline phosphatase, IgM, white blood cell count, prothrombin time, partial thromboplastin time, and neutrophil numbers. There was an inverse correlation to hemoglobin. sIL-6R levels were not elevated. These observations demonstrate that IL-6 is a useful surrogate marker of severity of hematologic disease and suggest that IL-6 contributes to pathology.
- Journal title abbreviation:
- Clin Immunol
- Year:
- 2005
- Journal volume:
- 115
- Journal issue:
- 2
- Pages contribution:
- 216-23
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.clim.2005.01.011
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/15885646
- Print-ISSN:
- 1521-6616
- TUM Institution:
- Klinik und Poliklinik für Dermatologie und Allergologie
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