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Document type:
Journal Article; Article
Author(s):
Gillitzer, A; Peluso, M; Laugwitz, KL; Munch, G; Massberg, S; Konrad, I; Gawaz, M; Ungerer, M
Title:
Retroviral infection and selection of culture-derived platelets allows study of the effect of transgenes on platelet physiology ex vivo and on thrombus formation in vivo.
Abstract:
Background- We recently reported the development of culture-derived (CD) platelets with the aim to express any protein of interest in these platelets. We now report a specific protocol of retroviral infection into the progenitor cells and subsequent selection, which allows to generate large amounts of highly homogenous transgene-expressing CD platelets and to study transgene function rapidly and reliably at large-scale ex vivo and in vivo settings. METHODS AND RESULTS: After retroviral infection...     »
Journal title abbreviation:
Arterioscler Thromb Vasc Biol
Year:
2005
Journal volume:
25
Journal issue:
8
Pages contribution:
1750-5
Language:
eng
Fulltext / DOI:
doi:10.1161/01.ATV.0000172659.01157.c6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15933244
Print-ISSN:
1079-5642
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie)
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