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Document type:
journal article 
Author(s):
Staumont-Sallé, Delphine; Fleury, Sébastien; Lazzari, Anne; Molendi-Coste, Olivier; Hornez, Nicolas; Lavogiez, Céline; Kanda, Akira; Wartelle, Julien; Fries, Anissa; Pennino, Davide; Mionnet, Cyrille; Prawitt, Janne; Bouchaert, Emmanuel; Delaporte, Emmanuel; Glaichenhaus, Nicolas; Staels, Bart; Julia, Valérie; Dombrowicz, David 
Title:
CX?CL1 (fractalkine) and its receptor CX?CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin. 
Abstract:
Atopic dermatitis (AD) is a chronic allergic dermatosis characterized by epidermal thickening and dermal inflammatory infiltrates with a dominant Th2 profile during the acute phase, whereas a Th1 profile is characteristic of the chronic stage. Among chemokines and chemokine receptors associated with inflammation, increased levels of CX3CL1 (fractalkine) and its unique receptor, CX3CR1, have been observed in human AD. We have thus investigated their role and mechanism of action in experimental mo...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2014 
Journal volume:
211 
Journal issue:
Pages contribution:
1185-96 
Language:
eng 
Print-ISSN:
0022-1007 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung