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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Weskamp, Gisela; Ford, Jill W.; Sturgill, Jamie; Martin, Steve; Docherty, Andrew J P; Swendeman, Steven; Broadway, Neil; Hartmann, Dieter; Saftig, Paul; Umland, Shelby; Sehara-Fujisawa, Atsuko; Black, Roy A.; Ludwig, Andreas; Becherer, J. David; Conrad, Daniel H.; Blobel, Carl P. 
Titel:
ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23 
Abstract:
CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The proteolytic release of CD23 from cells is considered a key event in the allergic response. Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify A...    »
 
Zeitschriftentitel:
Nature immunology 
Jahr:
2006 
Band / Volume:
Heft / Issue:
12 
Seitenangaben Beitrag:
1293--1298 
Print-ISSN:
1529-2908