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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Maretzky, Thorsten; McIlwain, David R.; Issuree, Priya Darshinee A; Li, Xue; Malapeira, Jordi; Amin, Sadaf; Lang, Philipp A.; Mak, Tak W.; Blobel, Carl P. 
Titel:
iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding 
Abstract:
Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regulator of EGF-receptor signaling and TNF\textgreek{a} release, is rapidly and posttranslationally activated by a variety of signaling pathways, and yet little is known about the underlying mechanism. Here, we report that inactive rhomboid protein 2 (iRhom2), recently identified as essential for the maturation of ADAM17 in hematopoietic cells, is crucial for the rapid activation of the shedding of some, b...    »
 
Zeitschriftentitel:
Proceedings of the National Academy of Sciences of the United States of America 
Jahr:
2013 
Band / Volume:
110 
Heft / Issue:
28 
Seitenangaben Beitrag:
11433--11438