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Document type:
journal article 
Author(s):
Langfelder, Antonia; Okonji, Emeka; Deca, Diana; Wei, Wei-Chun; Glitsch, Maike D 
Title:
Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia. 
Abstract:
Microglia are the resident macrophage and immune cell of the brain and are critically involved in combating disease and assaults on the brain. Virtually all brain pathologies are accompanied by acidosis of the interstitial fluid, meaning that microglia are exposed to an acidic environment. However, little is known about how extracellular acidosis impacts on microglial function. The activity of microglia is tightly controlled by'on' and'off' signals, the presence or absence of which results in ge...    »
 
Journal title abbreviation:
Cell Calcium 
Year:
2015 
Journal volume:
57 
Journal issue:
Pages contribution:
247-56 
Language:
eng 
Print-ISSN:
0143-4160 
TUM Institution:
Institut für Neurowissenschaften