User: Guest  Login
Document type:
journal article 
Author(s):
Willem, Michael; Tahirovic, Sabina; Busche, Marc Aurel; Ovsepian, Saak V; Chafai, Magda; Kootar, Scherazad; Hornburg, Daniel; Evans, Lewis D B; Moore, Steven; Daria, Anna; Hampel, Heike; Müller, Veronika; Giudici, Camilla; Nuscher, Brigitte; Wenninger-Weinzierl, Andrea; Kremmer, Elisabeth; Heneka, Michael T; Thal, Dietmar R; Giedraitis, Vilmantas; Lannfelt, Lars; Müller, Ulrike; Livesey, Frederick J; Meissner, Felix; Herms, Jochen; Konnerth, Arthur; Marie, Hélène; Haass, Christian 
Title:
?-Secretase processing of APP inhibits neuronal activity in the hippocampus. 
Abstract:
Alzheimer disease (AD) is characterized by the accumulation of amyloid plaques, which are predominantly composed of amyloid-? peptide. Two principal physiological pathways either prevent or promote amyloid-? generation from its precursor, ?-amyloid precursor protein (APP), in a competitive manner. Although APP processing has been studied in great detail, unknown proteolytic events seem to hinder stoichiometric analyses of APP metabolism in vivo. Here we describe a new physiological APP processin...    »
 
Journal title abbreviation:
Nature 
Year:
2015 
Journal volume:
526 
Journal issue:
7573 
Pages contribution:
443-7 
Language:
eng 
Print-ISSN:
0028-0836 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Institut für Neurowissenschaften